We proposed, for the first time, an efficient, generic and label-free enantioselective discrimination strategies by using surfaced-enhanced Raman scattering (SERS) spectroscopy through charge-transfer (CT) contributions. Herein, the two enatiomers of different kinds of alcohol molecules can be distinctly discriminated by the chiral selector (MPY), the relative intensities of which are strongly dependent on the chirality of its surroundings. This study opens a new avenue leading to the development of novel enantiosensing strategies.

Yue Wang, Zhi Yu, Wei Ji, Yoshito Tanaka, Huimin Sui, Bing Zhao, Yukihiro Ozaki

“Enantioselective Discrimination of Alcohols by Hydrogen Bonding: A SERS Study”

Angew. Chem. Int. Ed. DOI: 10.1002/anie.201407642